Brand Name

Generic Name

Trial Name

Manufacturer

Comments

Immunomodulatory Drugs (IMiDs)

Thalomid

Thalidomide

Celgene

All three have multiple mechanisms of anti-tumor action including modification of the immune system and anti-angiogenesis.

Revlimid

Lenalidomide

Celgene

Actimid (?)

Pomalidomide

CC-4047

Celgene

Corticosteroids

Decadron

Dexamethasone

Generic

Not sure why these steroids help, but "Everything works better with DEX."

Prednisone

Generic

Proteasome Inhibitors

Velcade

Bortezomib

PS-341

Millennium

These prevent rapidly-growing cells from discharging waste - both administered by infusion.

Kyprolis

Carfilzomib

PR-171

Onyx

Ixazomib

MLN9708

Millennium

First oral proteasome inhibitor

Alkylating Agents

Alkeran

Melphalan

GSK

These drugs attach to the DNA of rapidly-dividing cells, damaging that DNA and thus the cells, but can also affect some normal cells.

Cytoxan

Cyclophosphamide

Generic

Busulfex, Myleran

Busulfan

BCNU

Carmustine

Treanda

Bendamustine

SDX-105

Cephalon

Intercalating Agents

Adriamycin, Rubex

Doxorubicin

Generic

Actually a type of antibiotic

Doxil

Pegylated doxorubicin

Generic

Liopsome-encapsulated form, less toxic to the heart.

Biaxin

Clarithromycin

Antibiotic. These attach to DNA also

Mitotic Inhibitor

Oncovin

Vincristine

Generic

Derived from Madagascar periwinkle

Histone deacetylase (HDAC) inhibitors

Zolinza

Vorinostat

Patheon

Activates genes which should control normal cell activity but are inhibited in myeloma

Monoclonal Antibodies

Siltuximab

CNTO328

Janssen Biotech

Targets IL6, a myeloma growth factor. Also ovarian cancer?

BI-505

BioInvent

Targets ICAM-1

Elotuzumab

HuLuc63

Abbott/Squibb

Targets CS1

HuMax-CD38

Daratumumab

Genmab

Targets CD38

mTOR Inhibitor

Torisel

Temsirolimus

Inhibits mTOR, thereby blocking cell growth

Bone Treatments

Zometa

Zoledronic acid

Novartis

Bisphosphonate

Aredia

Pamidronate disodium

Novartis

Bisphosphonate

Prolia

Denosumab

Amgen

Monoclonal antibody targeting RANKL

Asparagine Inhibitor

Oncaspar

Pegaspargase

Sigma-Tau

Enzyme which destroys asparagine, needed by cancer cells

CK2 Inhibitor

CX-4945

Cylene

Inhibits CK2 enzyme, required for myeloma cell proliferation